Nested Knowledge offers a comprehensive software platform designed to support systematic literature reviews and meta-analyses with AI integration. The platform’s two main components work seamlessly together: AutoLit assists with searching, screening, data extraction, and final critical evaluations, while Synthesis allows users to visualize, assess, publish, and share their findings. Our AI tools are available at each step to accelerate research, query literature, build systematic reviews or other review types, and create living, continuously updateable versions of the evidence that address key medical research questions.