You must already be aware about the fact that FDA has already approved drugs that were used for diabetes such as semaglutide and tirzepatide with some modifications for weight loss as well. Also, it was seen that these drugs proved to be effective in reducing weight by as much as 3-4 kgs per month as it reduced the appetite. However, we now have reports where the FDA is investigating complaints from people who have suicidal thoughts and even hair loss after taking these drugs from quite some time now.
The FAERS website notes that “The appearance of a drug on this list does not mean that FDA has concluded that the drug has the listed risk”. “It means that the FDA has identified a potential safety issue, but it does not mean that FDA has identified a causal relationship between the drug and the listed risk.” FDA also suggests that “People who use these medications and have questions or concerns about side effects should speak with their health care provider”. The agency told CNN that “The FDA monitors the safety of drugs throughout their life cycle, including post-approval. In addition, the FDA maintains a system of postmarketing surveillance and risk assessment programs to identify and evaluate adverse events that did not appear during the drug development process”. “If newly identified safety signals are identified, the FDA will determine what, if any, actions are appropriate after a thorough review of available data.” The agency also mentioned that they are “evaluating the need for regulatory action” on these drugs.
In the same report, it is mentioned that “research has linked GLP-1 agonists to serious digestive problems such as stomach paralysis, pancreatitis and bowel obstructions, although the risks of these events appear to be rare. Many of these side effects are mentioned in the drugs’ prescribing information or on their labels”. It is worth noting that drugs like Wegovy, Ozempic and Mounjaro, also known as GLP-1 receptor agonists, are approved to treat diabetes or weight loss. Basically, it also tells you how these drugs work and adds that “They mimic GLP-1, a hormone made naturally in the body whose roles include slowing the passage of food through the stomach.”